Which feature favors Alzheimer's disease over dementia with Lewy bodies?

• A. Early memory impairment
• B. Early visuospatial deficits
• C. Early visual hallucinations
• D. Prominent parkinsonism early

Answer: (A)

Early memory impairment is most consistent with Alzheimer's disease because the disease targets the hippocampus and medial temporal structures early, leading to prominent anterograde amnesia and difficulty forming new memories. Dementia with Lewy bodies, on the other hand, typically shows early visuospatial deficits and visual hallucinations, with parkinsonian features often appearing early as well. So memory loss at the outset best distinguishes Alzheimer’s from DLB, while visuospatial problems, visual hallucinations, and early parkinsonism point more toward DLB.